Every male sperm has DNA imperfection, and if the level of imperfection is higher, this leads to sub-fertile and infertile men. High sperm DNA fragmentation can affect the reproductive outcomes and causes a lower success rate in natural pregnancy, IUI, IVF, and increase the chances of miscarriage.
Various factors are responsible for causing damage to the sperm DNA like abortive apoptosis, oxidative stress, UV rays, electronic instrument radiation, diabetes, obesity, enlarged testicular veins, and sedentary occupations.
DNA fragmentation can cause damage to the male sperm and is the major factor that causes subfertility and infertility in males. DNA Fragmentation Index is a type of diagnostic test performed to evaluate the amount or degree of fragmentation in the sperm.
The motility, concentration, and shape of the sperm play an important role in defining the quality of the sperm. With the help of the DFI test, one can avail more details about sperm fragmentation than conventional methods. The sperm fragmentation also leads to infertility, miscarriage, and chromosomal associated disease or abnormalities in the offspring.
If the sperm fragmentation is diagnosed early, it gives a clear picture of the viability of the sperm. Early diagnosis helps prevent further problems or stress caused by infertility and saves one from unfavorable outcomes associated with the fragmented sperm.
If one is facing difficulty conceiving, consult today with the best fertility specialist doctor and want to learn more about the DNA Fragmentation Index test in Delhi can visit Dr. Sowjanya Aggarwal IVF Clinic.
DNA Fragmentation Index (DFI) Test Procedure
The sperm sample is obtained, and then an expert embryologist evaluates the sperm sample through a series of diagnostic tests that help determine the amount or percentage of fragmentation in DNA. The test is carried out using an instrument called a flow cytometer, and stained cells are passed through a glass channel in a liquid suspension. A laser beam is used to emit fluorescent light of a specific color. The sperm with a lower level of fragmentation in DNA emits green fluoresce, and red is emitted by sperm that have a high to moderate level of DNA fragmentation. The percentage of DNA fragmentation in the sperm is expressed in the form of the DNA fragmentation Index.
With the treatment results, the specialist recommends lifestyle modification, some changes, and guides the patient towards the fertility treatment that offers the best outcomes.
This test is an ideal option for males who are above 45 years of age, suffering from unexplained infertility, female partner suffering from recurrent miscarriage, and detected with an abnormal semen analysis.
Suffering from infertility, visit today at Dr. Sowjanya Aggarwal IVF Clinic to overcome infertility issues and to achieve a healthy pregnancy.